JWH - 018

Тема в розділі 'Cannabinoids', створена користувачем Charles Darwin, 02.05.2014.

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    Charles Darwin

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    JWH-018(1-pentyl-3-(1-naphthoyl)indole) orAM-678

    is an
    chemical from the naphthoylindole family that acts as a
    at both the CB1and CB2cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of
    , a cannabinoid naturally present in Канабис, leading to its use in
    products such as "legal Канабис herbal incense blends" which in some countries are sold legally as "incense", labeled "not for human consumption".

    History

    , an organic chemist at
    , synthesized analogues and metabolites of
    (THC), the principal active component of Канабис. JWH-018 is one of these analogues, with studies showing an affinity for the cannabinoid (CB1) receptor five times greater than that of THC.
    are found in mammalian brain and spleen tissue; however, the structural details of the active sites are currently unknown.

    On December 15, 2008, it was reported by the German pharmaceutical company
    that JWH-018 was found as one of the active components in at least three versions of the herbal blend
    , which has been sold as an incense in a number of countries around the world since 2002. An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the compound had been replaced with
    .

    Pharmacology

    JWH-018 is a full agonist of both the CB1and CB2cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1and 2.94 ± 2.65 nM at CB2.

    Pharmacokinetics

    JWH-018 administered to rats resulted in the excretion of an indole-N-desalkyl metabolite as well as several hydroxylated metabolites in urine. The highest signals were observed for the hydroxylatedN-desalkyl metabolites. Hydroxylation took place on the side chain and in both aromatic systems, the naphthalene and the indole rings, as could be shown by mass shift of the corresponding fragments and by MS3experiments. Human metabolites were similar although most metabolism took place on the indole ring and pentyl side chain, and the hydroxylated metabolites were extensively conjugated with
    .

    Usage

    At least one case of JWH-018 dependence has been reported by the media. The user consumed JWH-018 daily for eight months. Withdrawal symptoms were similar to those experienced as a result of
    . JWH-018 has been shown to cause profound changes in CB1receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.

    On October 15, 2011, Anderson County coroner Greg Shore attributed the Dead of a South Carolina college basketball player to "drug toxicity and organ failure" caused by JWH-018. An email dated Nov 4, 2011 concerning the case was finally released by the city of Anderson S.C. on Dec 16, 2011 under the Freedom of Information Act after multiple requests by media to see the information had been denied.

    Compared to THC, which is a
    at CB1receptors, JWH-018 (and many of its analogues) are
    . THC has been shown to inhibit
    neurotransmission in the brain via several pathways. JWH-018 may cause intense anxiety, agitation, and, in rare cases (generally with non-regular JWH users), has been assumed to have been the cause of
    and
    by inhibiting GABA neurotransmission more effectively than THC. Cannabinoid receptor
    may present serious dangers to the user when used to excess.

    Various physical and psychological adverse effects have been reported from JWH-018 use. One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following JWH-018 inhalation. Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.

    Detection in biological fluids

    JWH-018 usage is readily detected in urine using "spice" screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites. JWH-018 will not be detected by older methods employed for detecting THC and other Канабис terpenoids. Determination of the parent drug in serum or its
    in urine has been accomplished by
    or
    . Serum JWH-018 concentrations are generally in the 1–10 μg/L range during the first few hours after recreational usage. The major urinary metabolite is a compound that is monohydroxylated on the omega minus one carbon atom of the alkyl side chain. A lesser metabolite monohydroxylated on the omega (terminal) position was present in the urine of 6 users of the drug at concentrations of 6–50 μg/L, primarily as a glucuronide conjugate.
     
    Charles Darwin, 02.05.2014
    #1